MIT grant awarded for joint research

We are happy and proud to share that a Research Grant has been awarded to LifeTec Group and Cardiac Booster! Following earlier work that was published at the end of last year (click here for the paper), both SME's were happy with the collaboration and decided to continue the joint research and applied for a Dutch MIT-research grant. With great support from Real1ze on the project proposal, the grant application was succesful and starting April 1st this exciting project will commence.

Increasing realism

LifeTec Group is always looking to improve their capabilities towards more relevant and realistic testing environments. In standardized pulse-duplicator testing, which is needed for regulatory approval of new cardiac devices, pre-defined testing conditions are simulated using such test setups. This is a great way to generate data on device performance, and allow comparison between different devices in the same situation. However, in real life, the human body immediately responds to a medical treatment so that the predefined testing condition no longer applies. This is especially evident in heart-support, where a failing heart is supported by an assist device that will unload the heart. Within the context of this research project, LifeTec Group wants to replace the predetermined situation with a simulation model that mimics the contraction of the heart. In that way our Heart Valve Assessment platform as well as our Cardiac BioSimulator platforms can simulate the hemodynamic response of the heart to treatment and intervention. As such we can focus on the success of the delivery procedure and on how the patient's immediate condition improves from the intervention, rather than characterize the performance of the isolated device.

The advantage of this approach is that the results obtained, and lessons learned, translate better to what happens in animal experiments or human clinical trials. This makes the concept very useful in early R&D, but also very applicable in clinical training of different scenarios as the simulator responds to what the trainees are doing.

Building on collaboration

 

The concept of contraction models is of course not new. Many academic and industrial research groups have been modeling the heart in the past. LifeTec Group is actively collaborating with the CardioVascular BioMechanics group at the Eindhoven University of Technology on the implementation of this concept who have a great track record on this topic.

New concept for heart support

Cardiac Booster

CardiacBooster is developing a novel device to treat patiens with severe heart failure. Treatment of such patients focuses on pharmacologic and hemodynamic support of the failing heart. Percutaneous (catheter-based) Ventricular Assist Devices (pVAD's) are already on the market, but the implantation of many of these is associated with relatively high risk of vascular and access site complications. The solution that CardiacBooster has in mind is less invasive, and should also be more friendly to the patient during its operation when compared to products that are currently on the market. The collaboration with LifeTec Group will allow CardiacBooster to efficiently study in an early stage how to effectively the device concept works in different situations in a low-risk but realistic flow simulator. This will speed up the development process, as the need for acute animal experiments is significantly lowered at this stage. Moreover, LifeTec's simulator platform can prove to be a great training tool for future users of the CardiacBooster VAD.

 

 

Speeding up by co-development

 

The intention of the collaboration is to speed up the development of both parties. CardiacBooster benefits from being able to test their prototypes fast, and in a very early stage have access to relevant data. LifeTec Group will develop an interactively controlled hemodynamic simulator, which will benefit from interacting with the ventricular assist device to verify clinical relevance. All together, the project accellerates the validation process, supports the development of medical devices, and elevates the acceptance of innovations.

 

Interested to learn more about this project? Please contact Marco.

Head of MedTech Innovation
Marco Stijnen
Call at +31 6 39279777 or e-mail us
Head of MedTech Innovation

Marco Stijnen

Senior Research Engineer

Sjoerd van Tuijl

R&D engineer

Dave Wanders

R&D Engineer

Marcel Wijlaars

R&D Engineer

Bart Smeets

R&D Engineer

Mattia D'Alessi

R&D Engineer

Bertus van de Wetering

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