First Coronary Artery Study in LifeTec Group's Vascular Bioreactor

First Coronary Artery Study in LifeTec Group's Vascular Bioreactor

A new milestone for LifeTec Group’s vascular bioreactor platform has recently been achieved: a pilot study using porcine coronary arteries has been successfully performed! 

 

[photo: Coronary artery mounted in culture chamber of LifeTec Group's Vascular Bioreactor (VABIO) platfom]

Until now, LifeTec Group’s VAscular BIOreactor platform (VABIO) has mainly been used to culture porcine carotid arteries. The applications for this model are in testing novel vascular device intervention concepts and drug-device combination products such as drug eluting balloons and drug eluting stents, but also in studying regenerative medicine approaches focusing on interaction of cell infiltration of porous vascular graft scaffolds.

The choice for carotid arteries was a pragmatic approach, as these have very few sidebranches which makes them easier to connect in a fluid circulation system. Carotid arteries, in fact, are a useful model for many applications, but they do have a slightly larger diameter and different anatomy. Since the final application for many devices and interventions is in coronary arteries, the need for culturing coronaries in addition to carotids is becoming stronger. 

“Coronary stent -in-a-box and -on-a-chip"

The coronary culturing is part of a Dutch grant project: “Coronary stent -in-a-box and -on-a-chip: Development and innovation of alternatives to swine coronary stent models for preclinical cardiovascular research”. In this project, LifeTec Group is collaborating with the Erasmus Medical Center and the Delft University to study improvements for medication and medicine carriers. A focus point is to use novel platforms such as VABIO (dubbed coronary stent-in-a-box) at LifeTec Group, while TU Delft is focusing on “on a chip” technology, both with a view to reduce the number of animal trials needed to bring such technologies to the market.

 

 

  • Figure 1: Coronary artery mounted in culture chamber of VABIO platform.
    Figure 1: Coronary artery mounted in culture chamber of VABIO platform.
    Figure 1: Coronary artery mounted in culture chamber of VABIO platform.
  • Figure 2: Coronary artery mounted in culture chamber of VABIO platform.
    Figure 2: Coronary artery mounted in culture chamber of VABIO platform.
    Figure 2: Coronary artery mounted in culture chamber of VABIO platform.
  • Figure 3: Vascular Bioreactor Platform (VABIO)
    Figure 3: Vascular Bioreactor Platform (VABIO)
    Figure 3: Vascular Bioreactor Platform (VABIO)

"Long-term culturing of coronaries"

Long-term culturing of coronaries would allow for testing of coronary stents, drug eluting balloons, intravascular imaging techniques and coronary interventional procedures, following the response of the native tissue up to several weeks, providing interesting insights which would be hard to obtain with in vitro or in vivo testing.

The use of coronaries in this platform follows the development of the other LifeTec´s ex vivo platforms combining animal tissue from slaughterhouse with bench-top hardware in the perspective of opening new possibilities to perform more realistic and relevant testing of novel devices and interventions. 

"human cadaveric material"

With the recent addition of using human cadaveric material in LifeTec Group’s lab, also possibilities open up in applying (pathological) cadaveric human coronary arteries in VABIO in the near future.

R&D Engineer Noemi Vanerio

Stay tuned for updates on this project! Meanwhile, if you have your own ideas on vascular projects and are interested in using VABIO, don’t hesitate to get in touch!

 

Noemi Vanerio

Phone: +31 40 298 93 93 | Email: n.vanerio@lifetecgroup.com

Head of MedTech Innovation

Marco Stijnen

R&D Engineer

Noemi Vanerio

R&D Engineer

Bart Smeets

Relevant links and background information:

-  “Coronary stent -in-a-box and -on-a-chip: Development and innovation of alternatives to swine coronary stent models for preclinical cardiovascular research

- "Coronary Stent In-A-Box and On-A-Chip" [news item | internal link]

- Vascular Bioreactor Platform (VABIO) [factsheet | internal link]

- "First Human Heart Study at LifeTec Group's Lab!" [news item | internal link]

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