Presentation at TERMIS 2021

In November of 2021, we attended the  6th world congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS). Alicia Ruppelt was granted a poster presentation about the research progress she's making on our BioLiver platform and her work within the SINERGIA program. The BioLiver is a living, functional, and metabolically active ex-vivo liver which is highly perfused with oxygen and nutrient rich blood with physiological flows and pressures. During the poster session she presented the results of successful perfusion of the liver over 12 hours and the first results from the assessment of the platform as pathology model.

Ex-Vivo Liver studies

Liver functionality was not only analyzed with liver markers but also with an indocyanine green functionality assay, which is a widely used quantitative liver function test. Due to the continuous bile production, the excretion of the green colored dye was clearly visible. Spectrometric analysis showed the clearance of the dye, which indicated functionality over 12 hours of perfusion.

Following the administration of abundant free fatty acids in the perfusion fluid,  the functionality of the liver was significantly decreased over time, which demonstrated the possibility of a pathology model. Further research will be done in the near future. If you wish to know more of our progress on the BioLiver platform or the SINERGIA project, please have a look at our BioLiver platform page or our SINERGIA project webpage.

For more information, please contact Alicia!

R&D Engineer
Alicia Ruppelt
Call at +31 40 2989393 or e-mail us

The project was funded by European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 860715.


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